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| Subtype | alpha2a | alpha2b | alpha2c |
| IUPHAR Code | 2.1.ADR.A2A.000.00.00 | 2.1.ADR.A2B.000.00.00 | 2.1.ADR.A2C.000.00.00 |
| Structure | 7TM h 450aa, PO8913, chr. 10q23-25 r 450aa, P22909 m 450aa, Q01338 |
7TM h 450aa, P18089, chr. 2 r 453aa, P19328 m 455aa, P30545 |
7TM h 461aa, P18825, chr. 4 r 458aa, P22086 m 458aa, Q 01337 |
| Agonists | oxymetazoline (partial) clonidne UK14304 |
alpha-methyl-NA clondine UK14304 |
alpha-methyl-NA clondine UK14304 |
| Antagonists | BRL44408 BRL48962 |
imiloxan | none |
| Native tissues | rabbit vas deferens dog saph. vein rabbit ear artery |
pressor response in mouse inhibits AC in NG108 cells |
human saph vein inhibits transmitter release (h. kidney & atrium |
| Antagonist potency | prazosin (KB = 460-1660nM) yohimbine (5.6nM) rauwolscine (6.6-15nM) BRL4408 (8.3-12nM) phentolamine (2.3-34nM) |
prazosin (KB = 39nM) yohimbine (3.4nM) |
prazosin (KB = 63-240nM) yohimbine (59nM) rauwolscine (0.8nM) BRL44408 (1910nM) |
Information taken from the IUPHAR Receptor Compendium | |||