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Information about alpha-1 adrenoceptors
| Subtype | alpha1a/A | alpha1b/B | alpha1d/D |
| IUPHAR Code | 2.1.ADR.A1A.000.00.00 | 2.1.ADR.A1B.000.00.00 | 2.1.ADR.A1D.000.00.00 |
| Structure | 7TM h 466aa, P35348, chr.8 r 466aa, P43140 |
7TM h 519aa, P35368, chr. 5 r 515aa, P15823 |
7TM h 572aa, P25100, chr. 20 r 561aa, P23944 m 562aa, P97714 |
| Agonists | Oxymetazoline A61603 |
N/A
|
N/A |
| Antagonists | 5-MU (+)niguildipine SNAP5089 |
CEC (irreversible; NS) | BMY7378 SKF105854 |
| Native tissues | rat tail artery rat vas deferens |
rat spleen mouse spleen |
rat aorta |
| Antagonist potency | prazosin (pA2 9-10) (+)niguldipine (9.5-10.5) |
prazosin (pA2 9-10) | prazosin (pA2 9-10) BMY7378 (8.0) |
Information taken from the IUPHAR Receptor Compendium | |||